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KMID : 0355220120370030161
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Journal of Korean Academy Oral Medicine
2012 Volume.37 No. 3 p.161 ~ p.167
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Clinical Features Affecting the Efficacy of Systemic Clonazepam for Management of Burning Mouth Syndrome
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Min Bo-Kyung
Jung Jae-Kwang
Choi Jae-Kap
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Abstract
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Burning mouth syndrome(BMS) is defined as chronic, painful burning sensation in the oral mucosa. Treatments for BMS include medication and psychiatric interventions. Capsaicin, alpha-lipoic acid, and topical and systemic clonazepam showed more effective in reducing the symptoms of BMS in the previous studies. The purpose of this study is to evaluate of the therapeutic efficacy of systemic clonazepam in BMS and to elucidate the relationships between such a efficacy and various clinical features, including age, pain intensity, pain duration, previous dental history and condition of oral mucosa. A retrospective clinical records audit was performed of patients diagnosed with BMS between January 2011 and August 2012. Patients were prescribed 0.5 mg clonazepam two times daily. Pain was assessed by patients on an 11-point numeric rating scale (NRS; 0 to 10) before and 1-2 weeks after systemic administration of clonazepam. The efficacy of clonazepam was evaluated in terms of patient’s age, initial pain intensity, pain duration, presence or absence of precipitating event, condition of the tongue, presence or absence of denture. A total of 50 patients (46 women, 4 men) were included in this study. The patients were divided into two or three groups according to above clinical features. The amount of mean NRS reduction in patients with severe initial pain was , whereas that in patients with mild initial pain was . The amount of mean NRS reduction in oldest patients was (70yrs), and those in another younger patients were (< 60yrs) and (60yrs age < 70yrs), respectively. It was concluded that the older patients and the patients with higher intensity of initial pain tend to show better efficacy of clonazepam. However, There were no statistically significant differences according to pain duration, presence or absence of precipitating events, tongue fissuring, and wearing dentures.
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KEYWORD
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Burning mouth syndrome, clonazepam
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